Protease Inhibitors and Phosphatase Inhibitors
MilliporeSigma™ Calbiochem™ Caffeine
Trimethylated xanthine that acts as a potent central nervous system stimulant.
MilliporeSigma™ Calbiochem™ InSolution™ Trichostatin A, Streptomyces sp.
A potent and reversible inhibitor of histone deacetylase
MilliporeSigma™ Calbiochem™ STAT3/STAT5 Dual Inhibitor, SH-4-54
A cell-permeable BP-1-102 analog that targets STAT3 and STAT5 with comparable affinity.
MilliporeSigma™ Calbiochem™ InSolution™ Tetrahydrouridine
Tetrahydrouridine is a potent competitive inhibitor of cytidine deaminase.
MilliporeSigma™ Calbiochem™ Calcineurin Substrate
An excellent peptide substrate for calcineurin.
MilliporeSigma™ Calbiochem™ Calyculin A, Discodermia calyx
Calyculin A, CAS 101932-71-2, is a cell-permeable inhibitor of protein phosphatase 2A (IC50 = 0.5-1 nM) and protein phosphatase 1 (PP1; IC50 = 2 nM).
MilliporeSigma™ Calbiochem™ Etomoxir
A cell-permeable, irreversible, and stereospecific compound that is shown to inhibit carnitine palmitoyltransferase (CPT)-1 and DGAT activity in the mitochondria of rat heart H9c2 myoblastic cells.
MilliporeSigma™ Calbiochem™ Dantrolene, Sodium Salt
A cell-permeable blocker of intracellular calcium release from the sarcoplasmic reticulum that acts by binding to the ryanodine receptor.
MilliporeSigma™ Calbiochem™ Cyclophosphamide Monohydrate
A widely used anti-neoplastic agent that also displays immunosuppressant properties.
MilliporeSigma™ Calbiochem™ Cypermethrin
Synthetic type II pyrethroid. Potent inhibitor of calcineurin (protein phosphatase 2B; IC50 = 40 pM). May also have varied effects on ion channels.
MilliporeSigma™ Calbiochem™ Oridonin, R. rubescens
A cell-permeable diterpenoid compound that possesses anti NF-κB activity and displays antiproliferative and antiangiogenic properties.
MilliporeSigma™ Calbiochem™ Nifedipine
Relatively selective blocker of L-type Ca2+ channels.
MilliporeSigma™ Calbiochem™ InSolution™ Nocodazole
Inhibitor of mitosis. Has highly specific antimicrotubular activity for mammalian cells in culture.
MilliporeSigma™ Calbiochem™ Nef Hck Activation Inhibitor, B9
A cell-permeable diphenylpyrazolo compound that disrupts HIV accessary protein Nef dimerization (IC50 = 3μM in HEK293T cells) and prevents Nef-mediated Src family kinase Hck activation (IC50 )
MilliporeSigma™ Calbiochem™ TACE Substrate IV, Fluorogenic
An internally-quenched fluorogenic decapeptide substrate that is useful for continuous monitoring of TACE activity and high-throughput screening of TACE inhibitors (kcat =